Like base analogs, alkylating agents induce mispairings between bases.
Alkylating agents, such as the chemical weapon mustard gas, add chemical
groups to the existing bases that make up DNA. As a consequence, the
altered bases pair with the wrong complement, thus introducing the mutation.
Surprisingly, alkylating agents are often used to fight cancer as part
of chemotherapy; therapeutic versions of alkylating agents may inhibit
cancer growth by interfering with the replication of DNA in rapidly dividing
cancer cells.
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